Characterization of the genetic determinants of context-specific DNA methylation in primary monocytes

To better understand inter-individual variation in sensitivity of DNA methylation (DNAm) to immune activity, we characterized effects of inflammatory stimuli on primary monocyte DNAm (n = 190). We find that monocyte DNAm is site-dependently sensitive to lipopolysaccharide (LPS), with LPS-induced dem...

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Bibliographic Details
Main Authors: Gilchrist, JJ, Fang, H, Danielli, S, Tomkova, M, Nassiri, I, Ng, E, Tong, O, Taylor, C, Muldoon, D, Cohen, LRZ, Al-Mossawi, H, Lau, E, Neville, M, Schuster-Boeckler, B, Knight, JC, Fairfax, BP
Format: Journal article
Language:English
Published: Cell Press 2024