Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition

<p>Individual risk of type 2 diabetes (T2D) is modified by perturbations of adipose mass, distribution and function. To investigate mechanisms responsible, we explored the molecular, cellular, and whole-body effects of T2D-associated alleles near KLF14. We show that KLF14 diabetes-risk alleles...

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Main Authors:	Small, KS, Todorčević, M, Civelek, M, Moustafa, JS, Wang, X, Simon, MM, Fernandez-Tajes, J, Mahajan, A, Horikoshis, M, Hugill, A, Glastonbury, CA, Quaye, L, Neville, MJ, Sethi, S, Yon, M, Pan, C, Che, N, Viñuela, A, Tsai, P-CC, Nag, A, Buil, A, Thorleifsson, G, Raghavan, A, Ding, Q, Morris, AP, Bell, JT, Thorsteinsdottir, U, Stefansson, K, Laakso, M, Dahlman, I, Arner, P, Gloyn, AL, Musunru, K, Lusis, AJ, Cox, RD, Karpe, F, McCarthy, M
Format:	Journal article
Published:	Nature Publishing Group 2018

Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition

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