Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition
<p>Individual risk of type 2 diabetes (T2D) is modified by perturbations of adipose mass, distribution and function. To investigate mechanisms responsible, we explored the molecular, cellular, and whole-body effects of T2D-associated alleles near KLF14. We show that KLF14 diabetes-risk alleles...
Main Authors: | Small, KS, Todorčević, M, Civelek, M, Moustafa, JS, Wang, X, Simon, MM, Fernandez-Tajes, J, Mahajan, A, Horikoshis, M, Hugill, A, Glastonbury, CA, Quaye, L, Neville, MJ, Sethi, S, Yon, M, Pan, C, Che, N, Viñuela, A, Tsai, P-CC, Nag, A, Buil, A, Thorleifsson, G, Raghavan, A, Ding, Q, Morris, AP, Bell, JT, Thorsteinsdottir, U, Stefansson, K, Laakso, M, Dahlman, I, Arner, P, Gloyn, AL, Musunru, K, Lusis, AJ, Cox, RD, Karpe, F, McCarthy, M |
---|---|
Format: | Journal article |
Published: |
Nature Publishing Group
2018
|
Similar Items
-
Adiposity-dependent regulatory effects on multi-tissue transcriptomes.
by: Glastonbury, C, et al.
Published: (2016) -
Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes
by: Small, K, et al.
Published: (2011) -
Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes
by: Small, K, et al.
Published: (2011) -
MicroRNA-196a links human body fat distribution to adipose tissue extracellular matrix composition
by: Hilton, C, et al.
Published: (2019) -
The Role of KLF2 in the Regulation of Atherosclerosis Development and Potential Use of KLF2-Targeted Therapy
by: Siarhei A. Dabravolski, et al.
Published: (2022-01-01)