The KDEL trafficking receptor exploits pH to tune the strength of an unusual short hydrogen bond

The endoplasmic reticulum (ER) is the main site of protein synthesis in eukaryotic cells and requires a high concentration of luminal chaperones to function. During protein synthesis, ER luminal chaperones are swept along the secretory pathway and must be retrieved to maintain cell viability. ER pro...

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Detalhes bibliográficos
Principais autores: Wu, Z, Newstead, S, Biggin, PC
Formato: Journal article
Idioma:English
Publicado em: Springer Nature 2020