The KDEL trafficking receptor exploits pH to tune the strength of an unusual short hydrogen bond

The endoplasmic reticulum (ER) is the main site of protein synthesis in eukaryotic cells and requires a high concentration of luminal chaperones to function. During protein synthesis, ER luminal chaperones are swept along the secretory pathway and must be retrieved to maintain cell viability. ER pro...

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Bibliographic Details
Main Authors: Wu, Z, Newstead, S, Biggin, PC
Format: Journal article
Language:English
Published: Springer Nature 2020