Pitfalls in estimating piperaquine elimination.

Pitfalls in estimating piperaquine elimination.

By using a sensitive new assay, the terminal elimination half-life of the antimalarial piperaquine in a healthy volunteer was estimated to be 33 days, which is longer than estimated previously. This result illustrates the importance of extended sampling duration and sensitive assay methodologies in...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Tarning, J, Lindegårdh, N, Annerberg, A, Singtoroj, T, Day, N, Ashton, M, White, N
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	2005

Eitemau Tebyg

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Characterization of human urinary metabolites of the antimalarial piperaquine.
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Population pharmacokinetic assessment of the effect of food on piperaquine bioavailability in patients with uncomplicated malaria.
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A new approach to evaluate regression models during validation of bioanalytical assays.
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A new approach to evaluate regression models during validation of bioanalytical assays
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Quantification of the antimalarial piperaquine in plasma.
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A small amount of fat does not affect piperaquine exposure in patients with malaria.
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A small amount of fat does not affect piperaquine exposure in patients with malaria.
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Population pharmacokinetics of piperaquine after two different treatment regimens of dihydroartemisinin piperaquine in patients with acute uncomplicated falciparum malaria in Thailand
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Population pharmacokinetics of piperaquine after two different treatment regimens with dihydroartemisinin-piperaquine in patients with Plasmodium falciparum malaria in Thailand.
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Development and validation of a liquid chromatographic-tandem mass spectrometric method for determination of piperaquine in plasma stable isotope labeled internal standard does not always compensate for matrix effects.
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Comparison of plasma, venous and capillary blood levels of piperaquine in patients with uncomplicated falciparum malaria.
gan: Ashley, E, et al.
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Comparison of plasma, venous and capillary blood levels of piperaquine in patients with uncomplicated falciparum malaria
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A population pharmacokinetic model of piperaquine in pregnant and non-pregnant women with uncomplicated Plasmodium falciparum malaria in Sudan.
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Population pharmacokinetics of dihydroartemisinin and piperaquine in pregnant and nonpregnant women with uncomplicated malaria.
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Population Pharmacokinetics of Dihydroartemisinin and Piperaquine in Pregnant and Nonpregnant Women with Uncomplicated Malaria
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Population pharmacokinetics and pharmacodynamics of piperaquine in children with uncomplicated falciparum malaria.
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Population pharmacokinetics and pharmacodynamics of piperaquine in children with uncomplicated falciparum malaria
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Efficacy and day 7 plasma piperaquine concentrations in African children treated for uncomplicated malaria with dihydroartemisinin-piperaquine
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Identification of an isomer impurity in piperaquine drug substance.
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Automated solid-phase extraction method for the determination of piperaquine in whole blood by rapid liquid chromatography.
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Automated solid-phase extraction method for the determination of piperaquine in plasma by peak compression liquid chromatography.
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Pharmacokinetics of piperaquine in pregnant women in Sudan with uncomplicated Plasmodium falciparum malaria.
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Pharmacokinetics of piperaquine in pregnant women in Sudan with uncomplicated Plasmodium falciparum malaria
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Pharmacokinetics of dihydroartemisinin and piperaquine in pregnant and nonpregnant women with uncomplicated falciparum malaria.
gan: Rijken, M, et al.
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Development and validation of a solid-phase extraction-liquid chromatographic method for determination of amoxicillin in plasma.
gan: Lindeg?rdh, N, et al.
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Efficacy and safety of dihydroartemisinin-piperaquine.
gan: Myint, H, et al.
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Population pharmacokinetics and electrocardiographic effects of dihydroartemisinin-piperaquine in healthy volunteers
gan: Chotsiri, P, et al.
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High throughput assay for the determination of piperaquine in plasma.
gan: Lindeg?rdh, N, et al.
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Efficacy and day 7 plasma piperaquine concentrations in African children treated for uncomplicated malaria with dihydroartemisinin-piperaquine.
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Population Pharmacokinetics and Antimalarial Pharmacodynamics of Piperaquine in Patients With Plasmodium vivax Malaria in Thailand.
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Population pharmacokinetics and antimalarial pharmacodynamics of piperaquine in patients with plasmodium vivax malaria in Thailand
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Characterization of an in vivo concentration-effect relationship for piperaquine in malaria chemoprevention.
gan: Bergstrand, M, et al.
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High throughput assay for the determination of lumefantrine in plasma.
gan: Annerberg, A, et al.
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Randomized, double-blind, placebo-controlled trial of monthly versus bimonthly dihydroartemisinin-piperaquine chemoprevention in adults at high risk of malaria
gan: Lwin, K, et al.
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Randomized, double-blind, placebo-controlled trial of monthly versus bimonthly dihydroartemisinin-piperaquine chemoprevention in adults at high risk of malaria.
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