All-optical electrophysiology refines populations of in silico human iPSC-CMs for drug evaluation

High-throughput in vitro drug assays have been impacted by recent advances in human induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) technology and by contact-free all-optical systems simultaneously measuring action potentials (APs) and Ca2+ transients (CaTrs). Parallel computational a...

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Bibliographic Details
Main Authors: Paci, M, Passini, E, Klimas, A, Severi, S, Hyttinen, J, Rodriguez, B, Entcheva, E
Format: Journal article
Language:English
Published: Elsevier 2020