Much of the genetic risk of colorectal cancer is likely to be mediated through susceptibility to adenomas.

Much of the genetic risk of colorectal cancer is likely to be mediated through susceptibility to adenomas.

Several single-nucleotide polymorphisms (SNPs) have been associated with colorectal cancer (CRC) susceptibility. Most CRCs arise from adenomas, and SNPs therefore might affect predisposition to CRC by increasing adenoma risk. We found that 8 of 18 known CRC-associated SNPs (rs10936599, rs6983267, rs...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Carvajal-Carmona, L, Zauber, A, Jones, A, Howarth, K, Wang, J, Cheng, T, Riddell, R, Lanas, A, Morton, D, Bertagnolli, M, Tomlinson, I
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	2013

Παρόμοια τεκμήρια

TERC polymorphisms are associated both with susceptibility to colorectal cancer and with longer telomeres
ανά: Jones, A, κ.ά.
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ανά: Jones, A, κ.ά.
Έκδοση: (2012)

Genetic Variants Associated with Colorectal Adenoma Susceptibility.
ανά: Anna Abulí, κ.ά.
Έκδοση: (2016-01-01)

Homozygous PMS2 deletion causes a severe colorectal cancer and multiple adenoma phenotype without extraintestinal cancer.
ανά: Will, O, κ.ά.
Έκδοση: (2007)

Fine Mapping of Colorectal Cancer Low Penetrance Susceptibility Loci
ανά: Carvajal-Carmona, L, κ.ά.
Έκδοση: (2009)

Multiple rare variants in different genes account for multifactorial inherited susceptibility to colorectal adenomas.
ανά: Fearnhead, N, κ.ά.
Έκδοση: (2004)

Analysis of copy number changes suggests chromosomal instability in a minority of large colorectal adenomas.
ανά: Jones, A, κ.ά.
Έκδοση: (2007)

APC mutations are sufficient for the growth of early colorectal adenomas.
ανά: Lamlum, H, κ.ά.
Έκδοση: (2000)

Erratum: Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas (Nature Genetics (2013) 45 (136-144))
ανά: Palles, C, κ.ά.
Έκδοση: (2013)

Bottom-up histogenesis of colorectal adenomas: origin in the monocryptal adenoma and initial expansion by crypt fission.
ανά: Preston, S, κ.ά.
Έκδοση: (2003)

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ανά: Palles, C, κ.ά.
Έκδοση: (2013)

The spectrum of p53 mutations in colorectal adenomas differs from that in colorectal carcinomas.
ανά: Hao, X, κ.ά.
Έκδοση: (2002)

Rare variant hypothesis for multifactorial inheritance: susceptibility to colorectal adenomas as a model.
ανά: Fearnhead, N, κ.ά.
Έκδοση: (2005)

Deciphering the genetic architecture of low-penetrance susceptibility to colorectal cancer.
ανά: Whiffin, N, κ.ά.
Έκδοση: (2013)

The multiple colorectal adenoma phenotype and MYH, a base excision repair gene.
ανά: Lipton, L, κ.ά.
Έκδοση: (2004)

Meat, vegetables and genetic polymorphisms and the risk of colorectal carcinomas and adenomas
ανά: Hansteen Inger-Lise, κ.ά.
Έκδοση: (2007-12-01)

Regression of colorectal adenoma
ανά: Subin Song, κ.ά.
Έκδοση: (2023-07-01)

Synchronous colorectal adenomas
ανά: Radovanović-Dinić Biljana, κ.ά.
Έκδοση: (2010-01-01)

Inherited susceptibility to colorectal adenomas and carcinomas: evidence for a new predisposition gene on 15q14-q22.
ανά: Tomlinson, I, κ.ά.
Έκδοση: (1999)

Investigation of pathogenic mechanisms in multiple colorectal adenoma patients without germline APC or MYH/MUTYH mutations.
ανά: Thirlwell, C, κ.ά.
Έκδοση: (2007)

A two-phase case-control study for colorectal cancer genetic susceptibility: candidate genes from chromosomal regions 9q22 and 3q22.
ανά: Abulí, A, κ.ά.
Έκδοση: (2011)

A two-phase case-control study for colorectal cancer genetic susceptibility: candidate genes from chromosomal regions 9q22 and 3q22
ανά: Abulí, A, κ.ά.
Έκδοση: (2011)

Fusobacterium is associated with colorectal adenomas.
ανά: Amber N McCoy, κ.ά.
Έκδοση: (2013-01-01)

Adiposity factors are not related to the presence of colorectal adenomas
ανά: Chronis A, κ.ά.
Έκδοση: (2011-11-01)

Frequency of germline hereditary non-polyposis colorectal cancer gene mutations in patients with multiple or early onset colorectal adenomas.
ανά: Beck, N, κ.ά.
Έκδοση: (1997)

Evidence against a major genetic basis for combined breast and colorectal cancer susceptibility.
ανά: Brinkman, H, κ.ά.
Έκδοση: (2006)

Association of plasma C-reactive protein level with the prevalence of colorectal adenoma: the Colorectal Adenoma Study in Tokyo
ανά: Nano Kigawa, κ.ά.
Έκδοση: (2017-06-01)

Reduced expression of molecules of the cadherin/catenin complex in the transition from colorectal adenoma to carcinoma.
ανά: Hao, X, κ.ά.
Έκδοση: (1997)

Top down or bottom up: competing management strategies in the histogenesis of colorectal adenomas
ανά: Wong, R, κ.ά.
Έκδοση: (2002)

Pleomorphic adenoma parotid surgery, how much margin we can reach to be safe?
ανά: Saleh Mohebbi, κ.ά.
Έκδοση: (2025-02-01)

Loss of expression and promoter methylation of SLIT2 are associated with sessile serrated adenoma formation
ανά: Beggs, A, κ.ά.
Έκδοση: (2013)

DNA aneuploidy in colorectal adenomas: Role in the adenoma-carcinoma sequence Aneuploidía del ADN en adenomas colónicos: Papel en la secuencia adenoma-carcinoma
ανά: M. Alcántara Torres, κ.ά.
Έκδοση: (2005-01-01)

Comprehensive mutation analysis in colorectal flat adenomas.
ανά: Quirinus J M Voorham, κ.ά.
Έκδοση: (2012-01-01)

Presence of Iron in Colorectal Adenomas and Adenocarcinomas
Έκδοση: (2008-06-01)

Multiple colorectal adenomas in Lynch syndrome
ανά: Ayushi Jain, κ.ά.
Έκδοση: (2022-12-01)

Age at menarche and risk of colorectal adenoma
ανά: Nam Hee Kim, κ.ά.
Έκδοση: (2019-09-01)

Top down or bottom up morphogenesis of colorectal adenomas: Competing management structures in the origins of colorectal neoplasia
ανά: Preston, S, κ.ά.
Έκδοση: (2003)

Common colorectal cancer risk alleles contribute to the multiple colorectal adenoma phenotype, but do not influence colonic polyposis in FAP.
ανά: Cheng, T, κ.ά.
Έκδοση: (2014)

The Influence of the Genetic and Immunologic Context in the Development of Colorectal Adenoma: A Case Series Report
ανά: Diogo Garcia, κ.ά.
Έκδοση: (2020-05-01)

Genetic pathways in colorectal cancer.
ανά: Ilyas, M, κ.ά.
Έκδοση: (1996)