Adipocyte Pseudohypoxia Suppresses Lipolysis and Facilitates Benign Adipose Tissue Expansion.

Prolyl hydroxylase enzymes (PHDs) sense cellular oxygen upstream of hypoxia-inducible factor (HIF) signaling, leading to HIF degradation in normoxic conditions. In this study, we demonstrate that adipose PHD2 inhibition plays a key role in the suppression of adipocyte lipolysis. Adipose Phd2 gene ab...

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Príomhchruthaitheoirí: Michailidou, Z, Morton, N, Moreno Navarrete, J, West, C, Stewart, K, Fernández-Real, J, Schofield, C, Seckl, JR, Ratcliffe, P
Formáid: Journal article
Teanga:English
Foilsithe / Cruthaithe: 2014