Biallelic FBXW7 knockout induces AKAP8-mediated DNA damage in 2 neighbouring wildtype cells

Colorectal cancer possesses marked intratumoral heterogeneity. While subclonal interactions between Vogelstein driver mutations have been extensively studied, less is known about competitive or cooperative effects between subclonal populations with other cancer driver mutations. FBXW7 is a cancer dr...

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Bibliographic Details
Main Authors: Chan, D, Mandal, A, Hester, S, Yu, Z, Higgins, G, Kessler, B, Fischer, R, Buczacki, S
Format: Journal article
Language:English
Published: Springer Nature 2023