Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model.

Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model.

The pathological end-state of Parkinson disease is well described from postmortem tissue, but there remains a pressing need to define early functional changes to susceptible neurons and circuits. In particular, mechanisms underlying the vulnerability of the dopamine neurons of the substantia nigra p...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Janezic, S, Threlfell, S, Dodson, P, Dowie, M, Taylor, T, Potgieter, D, Parkkinen, L, Senior, S, Anwar, S, Ryan, B, Deltheil, T, Kosillo, P, Cioroch, M, Wagner, K, Ansorge, O, Bannerman, D, Bolam, J, Magill, P, Cragg, S, Wade-Martins, R
Format: Journal article
Sprache:English
Veröffentlicht: National Academy of Sciences 2013

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