Brain mechanisms associated with depressive relapse and associated cognitive impairment following acute tryptophan depletion.

BACKGROUND: Acute tryptophan depletion lowers brain serotonin synthesis and results in a transient, but striking, clinical relapse in recovered depressed patients. AIMS: To identify brain regions which change their activity as an acute depressive relapse evolves and to determine how pathological moo...

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Bibliographic Details
Main Authors: Smith, K, Morris, J, Friston, K, Cowen, P, Dolan, R
Format: Journal article
Language:English
Published: 1999