A gamma34.5 mutant of herpes simplex 1 causes severe inflammation in the brain.
A number of viral vectors are currently being evaluated as potential gene therapy vectors for gene delivery to the brain. As well as evaluating their ability to express a transgene for extended periods of time it is also essential to examine any cytotoxic immune response to such vectors as this may...
Autors principals: | McMenamin, M, Byrnes, A, Charlton, H, Coffin, R, Latchman, D, Wood, M |
---|---|
Format: | Journal article |
Idioma: | English |
Publicat: |
1998
|
Ítems similars
-
Potential and limitations of a gamma 34.5 mutant of herpes simplex 1 as a gene therapy vector in the CNS.
per: McMenamin, M, et al.
Publicat: (1998) -
The Herpes Simplex Virus Neurovirulence Factor γ34.5: Revealing Virus-Host Interactions.
per: Douglas R Wilcox, et al.
Publicat: (2016-03-01) -
Herpes Simplex Virus γ34.5 Interferes with Autophagosome Maturation and Antigen Presentation in Dendritic Cells
per: Philipe A. M. Gobeil, et al.
Publicat: (2012-11-01) -
Early virion-associated suppression of cellular protein synthesis by herpes simplex virus is accompanied by inactivation of mRNA.
per: Fenwick, M, et al.
Publicat: (1984) -
Preclinical Toxicology of rQNestin34.5v.2: An Oncolytic Herpes Virus with Transcriptional Regulation of the ICP34.5 Neurovirulence Gene
per: E. Antonio Chiocca, et al.
Publicat: (2020-06-01)