A gamma34.5 mutant of herpes simplex 1 causes severe inflammation in the brain.
A number of viral vectors are currently being evaluated as potential gene therapy vectors for gene delivery to the brain. As well as evaluating their ability to express a transgene for extended periods of time it is also essential to examine any cytotoxic immune response to such vectors as this may...
Κύριοι συγγραφείς: | McMenamin, M, Byrnes, A, Charlton, H, Coffin, R, Latchman, D, Wood, M |
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Μορφή: | Journal article |
Γλώσσα: | English |
Έκδοση: |
1998
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Παρόμοια τεκμήρια
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Potential and limitations of a gamma 34.5 mutant of herpes simplex 1 as a gene therapy vector in the CNS.
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The Herpes Simplex Virus Neurovirulence Factor γ34.5: Revealing Virus-Host Interactions.
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Early virion-associated suppression of cellular protein synthesis by herpes simplex virus is accompanied by inactivation of mRNA.
ανά: Fenwick, M, κ.ά.
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Preclinical Toxicology of rQNestin34.5v.2: An Oncolytic Herpes Virus with Transcriptional Regulation of the ICP34.5 Neurovirulence Gene
ανά: E. Antonio Chiocca, κ.ά.
Έκδοση: (2020-06-01)