A gamma34.5 mutant of herpes simplex 1 causes severe inflammation in the brain.
A number of viral vectors are currently being evaluated as potential gene therapy vectors for gene delivery to the brain. As well as evaluating their ability to express a transgene for extended periods of time it is also essential to examine any cytotoxic immune response to such vectors as this may...
Glavni autori: | McMenamin, M, Byrnes, A, Charlton, H, Coffin, R, Latchman, D, Wood, M |
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Format: | Journal article |
Jezik: | English |
Izdano: |
1998
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Slični predmeti
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Potential and limitations of a gamma 34.5 mutant of herpes simplex 1 as a gene therapy vector in the CNS.
od: McMenamin, M, i dr.
Izdano: (1998) -
The Herpes Simplex Virus Neurovirulence Factor γ34.5: Revealing Virus-Host Interactions.
od: Douglas R Wilcox, i dr.
Izdano: (2016-03-01) -
Herpes Simplex Virus γ34.5 Interferes with Autophagosome Maturation and Antigen Presentation in Dendritic Cells
od: Philipe A. M. Gobeil, i dr.
Izdano: (2012-11-01) -
Early virion-associated suppression of cellular protein synthesis by herpes simplex virus is accompanied by inactivation of mRNA.
od: Fenwick, M, i dr.
Izdano: (1984) -
Preclinical Toxicology of rQNestin34.5v.2: An Oncolytic Herpes Virus with Transcriptional Regulation of the ICP34.5 Neurovirulence Gene
od: E. Antonio Chiocca, i dr.
Izdano: (2020-06-01)