Interleukin-2 can prevent and reverse antigen-induced unresponsiveness in cloned human T lymphocytes.
The exposure of human T-cell clones to supra-immunogenic concentrations of peptide antigen in the absence of accessory cells induces antigen-specific unresponsiveness. Using this model we have investigated the ability of cytokines to modulate the induction of, or reversal of, T-cell tolerance. Our f...
| Prif Awduron: | , , |
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| Fformat: | Journal article |
| Iaith: | English |
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1988
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| _version_ | 1826298594280341504 |
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| author | Essery, G Feldmann, M Lamb, JR |
| author_facet | Essery, G Feldmann, M Lamb, JR |
| author_sort | Essery, G |
| collection | OXFORD |
| description | The exposure of human T-cell clones to supra-immunogenic concentrations of peptide antigen in the absence of accessory cells induces antigen-specific unresponsiveness. Using this model we have investigated the ability of cytokines to modulate the induction of, or reversal of, T-cell tolerance. Our findings demonstrate that interleukin-2 (IL-2), but not interferon-gamma (IFN-gamma) or interleukin-1 (IL-1), is able to inhibit the induction of T-cell unresponsiveness in a dose-dependent fashion. Moreover, IL-2 was able to reverse established antigen-dependent T-cell unresponsiveness. In order to determine if modulation of IL-2 receptors is able to induce or abrogate unresponsiveness, the T cells were treated with anti-Tac antibody alone or together with tolerizing concentrations of antigen. Anti-Tac antibody was neither able to induce nor inhibit the induction of tolerance. The application of this model in the manipulation of immune responses is discussed here. |
| first_indexed | 2024-03-07T04:49:15Z |
| format | Journal article |
| id | oxford-uuid:d463e45d-10b4-4a10-b947-cc4e6493f60a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:49:15Z |
| publishDate | 1988 |
| record_format | dspace |
| spelling | oxford-uuid:d463e45d-10b4-4a10-b947-cc4e6493f60a2022-03-27T08:18:12ZInterleukin-2 can prevent and reverse antigen-induced unresponsiveness in cloned human T lymphocytes.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d463e45d-10b4-4a10-b947-cc4e6493f60aEnglishSymplectic Elements at Oxford1988Essery, GFeldmann, MLamb, JRThe exposure of human T-cell clones to supra-immunogenic concentrations of peptide antigen in the absence of accessory cells induces antigen-specific unresponsiveness. Using this model we have investigated the ability of cytokines to modulate the induction of, or reversal of, T-cell tolerance. Our findings demonstrate that interleukin-2 (IL-2), but not interferon-gamma (IFN-gamma) or interleukin-1 (IL-1), is able to inhibit the induction of T-cell unresponsiveness in a dose-dependent fashion. Moreover, IL-2 was able to reverse established antigen-dependent T-cell unresponsiveness. In order to determine if modulation of IL-2 receptors is able to induce or abrogate unresponsiveness, the T cells were treated with anti-Tac antibody alone or together with tolerizing concentrations of antigen. Anti-Tac antibody was neither able to induce nor inhibit the induction of tolerance. The application of this model in the manipulation of immune responses is discussed here. |
| spellingShingle | Essery, G Feldmann, M Lamb, JR Interleukin-2 can prevent and reverse antigen-induced unresponsiveness in cloned human T lymphocytes. |
| title | Interleukin-2 can prevent and reverse antigen-induced unresponsiveness in cloned human T lymphocytes. |
| title_full | Interleukin-2 can prevent and reverse antigen-induced unresponsiveness in cloned human T lymphocytes. |
| title_fullStr | Interleukin-2 can prevent and reverse antigen-induced unresponsiveness in cloned human T lymphocytes. |
| title_full_unstemmed | Interleukin-2 can prevent and reverse antigen-induced unresponsiveness in cloned human T lymphocytes. |
| title_short | Interleukin-2 can prevent and reverse antigen-induced unresponsiveness in cloned human T lymphocytes. |
| title_sort | interleukin 2 can prevent and reverse antigen induced unresponsiveness in cloned human t lymphocytes |
| work_keys_str_mv | AT esseryg interleukin2canpreventandreverseantigeninducedunresponsivenessinclonedhumantlymphocytes AT feldmannm interleukin2canpreventandreverseantigeninducedunresponsivenessinclonedhumantlymphocytes AT lambjr interleukin2canpreventandreverseantigeninducedunresponsivenessinclonedhumantlymphocytes |