Cell state-dependent allelic effects and contextual Mendelian randomization analysis for human brain phenotypes

Gene expression quantitative trait loci are widely used to infer relationships between genes and central nervous system (CNS) phenotypes; however, the effect of brain disease on these inferences is unclear. Using 2,348,438 single-nuclei profiles from 391 disease-case and control brains, we report 13...

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Main Authors:	Haglund, A, Zuber, V, Abouzeid, M, Yang, Y, Ko, JH, Wiemann, L, Otero-Jimenez, M, Muhammed, L, Feleke, R, Nott, A, Mills, JD, Laaniste, L, Gveric, DO, Clode, D, Babtie, AC, Pagni, S, Bellampalli, R, Somani, A, McDade, K, Anink, JJ, Mesarosova, L, Fancy, N, Willumsen, N, Smith, A
Format:	Journal article
Language:	English
Published:	Nature Research 2025

Cell state-dependent allelic effects and contextual Mendelian randomization analysis for human brain phenotypes

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