Loss of endothelial membrane KIT ligand affects systemic KIT ligand levels but not bone marrow hematopoietic stem cells

A critical regulatory role of hematopoietic stem cell (HSC) vascular niches in the bone marrow has been implicated to occur through endothelial niche cell expression of KIT ligand. However, endothelial-derived KIT ligand is expressed in both a soluble and membrane-bound form and not unique to bone m...

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Bibliographic Details
Main Authors: Matsuoka, S, Facchini, R, Luis, TC, Carrelha, J, Woll, PS, Mizukami, T, Wu, B, Boukarabila, H, Buono, M, Norfo, R, Arai, F, Suda, T, Mead, AJ, Nerlov, C, Jacobsen, SEW
Format: Journal article
Language:English
Published: American Society of Hematology 2023