The use of phosphate bioisosteres in medicinal chemistry and chemical biology
Phosphate and pyrophosphate groups play a central role in cellular signalling and consequently are of great interest to both medicinal chemists and chemical biologists. However, the design of molecules that can interfere with phosphate-based processes is recognised as a significant challenge, especi...
| Main Authors: | , , , |
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| Format: | Journal article |
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2012
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| _version_ | 1797097017819791360 |
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| author | Elliott, T Slowey, A Ye, Y Conway, S |
| author_facet | Elliott, T Slowey, A Ye, Y Conway, S |
| author_sort | Elliott, T |
| collection | OXFORD |
| description | Phosphate and pyrophosphate groups play a central role in cellular signalling and consequently are of great interest to both medicinal chemists and chemical biologists. However, the design of molecules that can interfere with phosphate-based processes is recognised as a significant challenge, especially when the resulting compounds must show good cellular penetration and stability. Herein, we have reviewed the full range of phosphate bioisosteres currently reported and provided the context of their deployment. We aim to provide a useful reference for medicinal chemists and chemical biologists who are engaged in the design of molecules that target phosphate-binding proteins. © The Royal Society of Chemistry 2012. |
| first_indexed | 2024-03-07T04:49:41Z |
| format | Journal article |
| id | oxford-uuid:d48692a7-0ab2-4ae3-8a40-9a946df95f09 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T04:49:41Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:d48692a7-0ab2-4ae3-8a40-9a946df95f092022-03-27T08:19:13ZThe use of phosphate bioisosteres in medicinal chemistry and chemical biologyJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d48692a7-0ab2-4ae3-8a40-9a946df95f09Symplectic Elements at Oxford2012Elliott, TSlowey, AYe, YConway, SPhosphate and pyrophosphate groups play a central role in cellular signalling and consequently are of great interest to both medicinal chemists and chemical biologists. However, the design of molecules that can interfere with phosphate-based processes is recognised as a significant challenge, especially when the resulting compounds must show good cellular penetration and stability. Herein, we have reviewed the full range of phosphate bioisosteres currently reported and provided the context of their deployment. We aim to provide a useful reference for medicinal chemists and chemical biologists who are engaged in the design of molecules that target phosphate-binding proteins. © The Royal Society of Chemistry 2012. |
| spellingShingle | Elliott, T Slowey, A Ye, Y Conway, S The use of phosphate bioisosteres in medicinal chemistry and chemical biology |
| title | The use of phosphate bioisosteres in medicinal chemistry and chemical biology |
| title_full | The use of phosphate bioisosteres in medicinal chemistry and chemical biology |
| title_fullStr | The use of phosphate bioisosteres in medicinal chemistry and chemical biology |
| title_full_unstemmed | The use of phosphate bioisosteres in medicinal chemistry and chemical biology |
| title_short | The use of phosphate bioisosteres in medicinal chemistry and chemical biology |
| title_sort | use of phosphate bioisosteres in medicinal chemistry and chemical biology |
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