HoxC5 and miR-615-3p target newly evolved genomic regions to repress hTERT and inhibit tumorigenesis

The repression of telomerase activity during cellular differentiation promotes replicative aging and functions as a physiological barrier for tumorigenesis in long-lived mammals, including humans. However, the underlying mechanisms remain largely unclear. Here we describe how miR-615-3p represses hT...

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Autors principals:	Yan, T, Ooi, W, Qamra, A, Cheung, A, Ma, D, Sundaram, G, Xu, C, Xing, M, Poon, L, Wang, J, Loh, Y, Ho, J, Ng, J, Ramlee, M, Aswad, L, Rozen, S, Ghosh, S, Bard, F, Sampath, P, Tergaonkar, V, Davies, J, Hughes, J, Goh, E, Bi, X, Fullwood, M, Tan, P, Li, S
Format:	Journal article
Idioma:	English
Publicat:	Nature Publishing Group 2018

HoxC5 and miR-615-3p target newly evolved genomic regions to repress hTERT and inhibit tumorigenesis

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