Inhibition of calcium uptake via the sarco/endoplasmic reticulum Ca2+-ATPase in a mouse model of Sandhoff disease and prevention by treatment with N-butyldeoxynojirimycin.

Inhibition of calcium uptake via the sarco/endoplasmic reticulum Ca2+-ATPase in a mouse model of Sandhoff disease and prevention by treatment with N-butyldeoxynojirimycin.

Gangliosides are found at high levels in neuronal tissues where they play a variety of important functions. In the gangliosidoses, gangliosides accumulate because of defective activity of the lysosomal proteins responsible for their degradation, usually resulting in a rapidly progressive neurodegene...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Pelled, D, Lloyd-Evans, E, Riebeling, C, Jeyakumar, M, Platt, F, Futerman, A
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	2003

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