Tetrahydroisoquinoline sulfamates as potent microtubule disruptors: synthesis, anti-proliferative and anti-tubulin activity of dichlorobenzyl-based derivatives and a tubulin co-crystal structure
Tetrahydroisoquinoline (THIQ) 6-O-sulfamate-based anticancer agents, inspired by the endogenous steroid 2-methoxyestradiol and its sulfamate derivatives, are further explored for antiproliferative and microtubule disruptor activity. Based on recently designed C3-methyl C7-methoxy-substituted THIQ de...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Published: |
American Chemical Society
2019
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