SPECIFIC-INHIBITION OF GLYCOGEN-PHOSPHORYLASE BY A SPIRODIKETOPIPERAZINE AT THE ANOMERIC POSITION OF GLUCOPYRANOSE

A key intermediate bicyclic lactone 6 allows control of the anomeric configuration of a spirodiketopiperazine of glucopyranose 5 which is a specific inhibitor of glycogen phosphorylase, showing no inhibition of α- and β-glucosidases, α- and β-galactosidases, β-N-acetylglucosaminidase, pectinase, xyl...

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Bibliographic Details
Main Authors: Krulle, T, Watson, K, Gregoriou, M, Johnson, L, Crook, S, Watkin, D, Griffiths, R, Nash, R, Tsitsanou, K, Zographos, S, Oikonomakos, N, Fleet, G
Format: Journal article
Published: 1995