The structure of the full-length tetrameric PKA regulatory RIIβ complex reveals the mechanism of allosteric PKA activation.
The catalytic activity of protein kinases is usually tightly controlled by posttranslational modifications and diverse sets of regulatory proteins. Protein kinases are highly dynamic enzymes, and structures of kinases in various activation states and costructures with regulatory proteins have provid...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2012
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