HDAC inhibitor-based therapies and haematological malignancy.

Reversible acetylation mediated by histone deacetylase (HDAC) influences a broad repertoire of physiological processes, many of which are aberrantly controlled in tumour cells. Since HDAC inhibition prompts tumour cells to enter apoptosis, small-molecule HDAC inhibitors have been developed as a new...

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Váldodahkkit: Stimson, L, Wood, V, Khan, O, Fotheringham, S, La Thangue, N
Materiálatiipa: Journal article
Giella:English
Almmustuhtton: 2009