The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation.

AIMS/HYPOTHESIS: Defects in pancreatic beta cell turnover are implicated in the pathogenesis of type 2 diabetes by genetic markers for diabetes. Decreased beta cell neogenesis could contribute to diabetes. The longevity and turnover of human beta cells is unknown; in rodents <1 year old, a ha...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Cnop, M, Hughes, S, Igoillo-Esteve, M, Hoppa, M, Sayyed, F, van de Laar, L, Gunter, J, de Koning, E, Walls, G, Gray, D, Johnson, P, Hansen, B, Morris, J, Pipeleers-Marichal, M, Cnop, I, Clark, A
Μορφή: Journal article
Γλώσσα:English
Έκδοση: 2010