Fumarate hydratase deletion in pancreatic beta cells leads to progressive diabetes

We explored the role of the Krebs cycle enzyme fumarate hydratase (FH) in glucose-stimulated insulin secretion (GSIS). Mice lacking Fh1 in pancreatic β cells (Fh1βKO mice) appear normal for 6-8 weeks but then develop progressive glucose intolerance and diabetes. Glucose tolerance is rescued by expre...

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Bibliographic Details
Main Authors:	Adam, J, Ramracheya, R, Chibalina, M, Ternette, N, Hamilton, A, Tarasov, A, Zhang, Q, Rebelato, E, Rorsman, N, Martín-Del-Río, R, Lewis, A, Özkan, G, Do, H, Spégel, P, Saitoh, K, Kato, K, Igarashi, K, Kessler, B, Pugh, C, Tamarit-Rodriguez, J, Mulder, H, Clark, A, Frizzell, N, Soga, T, Ashcroft, F, Silver, A, Pollard, P, Rorsman, P
Format:	Journal article
Language:	English
Published:	Elsevier 2017

Fumarate hydratase deletion in pancreatic beta cells leads to progressive diabetes

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