CD8+ T cells specific for conserved, cross-reactive Gag epitopes with strong ability to suppress HIV-1 replication

CD8+ T cells specific for conserved, cross-reactive Gag epitopes with strong ability to suppress HIV-1 replication

Background: Development of AIDS vaccines for effective prevention of circulating HIV-1 is required, but no trial has demonstrated definitive effects on the prevention. Several recent T-cell vaccine trials showed no protection against HIV-1 acquisition although the vaccines induced HIV-1-specific T-c...

Bibliográfalaš dieđut
Váldodahkkit:	Murakoshi, H, Zou, C, Kuse, N, Akahoshi, T, Chikata, T, Gatanaga, H, Oka, S, Hanke, T, Takiguchi, M
Materiálatiipa:	Journal article
Giella:	English
Almmustuhtton:	BioMed Central 2018

Geahča maid

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Differential clade-specific HLA-B*3501 association with HIV-1 disease outcome is linked to immunogenicity of a single Gag epitope.
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HIV-1 Escape from an HLA-B*13-Restricted Gag Epitope Affects the Gag-Pol Frameshift Stem-loop and Reduces Viral Fitness
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GagCM9-specific CD8+ T cells expressing limited public TCR clonotypes do not suppress SIV replication in vivo.
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Early presentation of HIV-1 KF11Gag and KK10Gag protective epitopes facilitate rapid CD8+T cell activation and killing of virus infected cells
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New Insights Into Retroviral Gag-Gag and Gag-Membrane Interactions
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Fusion of ubiquitin to HIV gag impairs human monocyte-derived dendritic cell maturation and reduces ability to induce gag T cell responses.
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Correction: The Effect of HLA Polymorphisms on the Recognition of Gag Epitopes in HIV-1 CRF01_AE Infection
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Gag-Gag Interactions Are Insufficient to Fully Stabilize and Order the Immature HIV Gag Lattice
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Orthoretroviral-like prototype foamy virus gag-pol expression is compatible with viral replication
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Effects of cytotoxic T lymphocytes (CTL) directed against a single simian immunodeficiency virus (SIV) Gag CTL epitope on the course of SIVmac239 infection.
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Impact of HLA-B*81-associated mutations in HIV-1 Gag on viral replication capacity.
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Almmustuhtton: (2012)

Role of transmitted Gag CTL polymorphisms in defining replicative capacity and early HIV-1 pathogenesis.
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The conserved histone chaperone Spt6 is strongly required for DNA replication and genome stability
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Strategy for identifying dendritic cell-processed CD4+ T cell epitopes from the HIV gag p24 protein.
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