Prolyl hydroxylase domain enzyme 2 is the major player in regulating hypoxic responses in rheumatoid arthritis.

Geahča maid

• Complement C1q is hydroxylated by collagen prolyl 4 hydroxylase, and is sensitive to off target inhibition by prolyl hydroxylase domain inhibitors that stabilise Hypoxia Inducible Factor
  Dahkki: Kiriakidis, S, et al.
  Almmustuhtton: (2017)
• Tissue expression and functional insights into HIF prolyl hydroxylase domain enzymes
  Dahkki: Wijeyekoon, JB
  Almmustuhtton: (2013)
• Regulation of HIF: prolyl hydroxylases.
  Dahkki: Stolze, I, et al.
  Almmustuhtton: (2006)
• Novel and selective small molecule inhibitors and activators for the prolyl hydroxylase domain enzyme
  Dahkki: Holt-Martyn, J
  Almmustuhtton: (2018)
• Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice.
  Dahkki: Walmsley, SR, et al.
  Almmustuhtton: (2011)