Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers.
CONTEXT: Recent studies have shown an association between cigarettes per day (CPD) and a nonsynonymous single-nucleotide polymorphism in CHRNA5, rs16969968. OBJECTIVE: To determine whether the association between rs16969968 and smoking is modified by age at onset of regular smoking. DATA SOURCES: Pr...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2012
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| _version_ | 1797097333985378304 |
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| author | Hartz, S Short, SE Saccone, N Culverhouse, R Chen, L Schwantes-An, T Coon, H Han, Y Stephens, S Sun, J Chen, X Ducci, F Dueker, N Franceschini, N Frank, J Geller, F Gubjartsson, D Hansel, N Jiang, C Keskitalo-Vuokko, K Liu, Z Lyytikäinen, L Michel, M Rawal, R Rosenberger, A |
| author_facet | Hartz, S Short, SE Saccone, N Culverhouse, R Chen, L Schwantes-An, T Coon, H Han, Y Stephens, S Sun, J Chen, X Ducci, F Dueker, N Franceschini, N Frank, J Geller, F Gubjartsson, D Hansel, N Jiang, C Keskitalo-Vuokko, K Liu, Z Lyytikäinen, L Michel, M Rawal, R Rosenberger, A |
| author_sort | Hartz, S |
| collection | OXFORD |
| description | CONTEXT: Recent studies have shown an association between cigarettes per day (CPD) and a nonsynonymous single-nucleotide polymorphism in CHRNA5, rs16969968. OBJECTIVE: To determine whether the association between rs16969968 and smoking is modified by age at onset of regular smoking. DATA SOURCES: Primary data. STUDY SELECTION: Available genetic studies containing measures of CPD and the genotype of rs16969968 or its proxy. DATA EXTRACTION: Uniform statistical analysis scripts were run locally. Starting with 94,050 ever-smokers from 43 studies, we extracted the heavy smokers (CPD >20) and light smokers (CPD ≤10) with age-at-onset information, reducing the sample size to 33,348. Each study was stratified into early-onset smokers (age at onset ≤16 years) and late-onset smokers (age at onset >16 years), and a logistic regression of heavy vs light smoking with the rs16969968 genotype was computed for each stratum. Meta-analysis was performed within each age-at-onset stratum. DATA SYNTHESIS: Individuals with 1 risk allele at rs16969968 who were early-onset smokers were significantly more likely to be heavy smokers in adulthood (odds ratio [OR] = 1.45; 95% CI, 1.36-1.55; n = 13,843) than were carriers of the risk allele who were late-onset smokers (OR = 1.27; 95% CI, 1.21-1.33, n = 19,505) (P = .01). CONCLUSION: These results highlight an increased genetic vulnerability to smoking in early-onset smokers. |
| first_indexed | 2024-03-07T04:54:02Z |
| format | Journal article |
| id | oxford-uuid:d5f8ed71-2064-4cda-a9f0-cd3d09d5d1a9 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:54:02Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:d5f8ed71-2064-4cda-a9f0-cd3d09d5d1a92022-03-27T08:29:58ZIncreased genetic vulnerability to smoking at CHRNA5 in early-onset smokers.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d5f8ed71-2064-4cda-a9f0-cd3d09d5d1a9EnglishSymplectic Elements at Oxford2012Hartz, SShort, SESaccone, NCulverhouse, RChen, LSchwantes-An, TCoon, HHan, YStephens, SSun, JChen, XDucci, FDueker, NFranceschini, NFrank, JGeller, FGubjartsson, DHansel, NJiang, CKeskitalo-Vuokko, KLiu, ZLyytikäinen, LMichel, MRawal, RRosenberger, ACONTEXT: Recent studies have shown an association between cigarettes per day (CPD) and a nonsynonymous single-nucleotide polymorphism in CHRNA5, rs16969968. OBJECTIVE: To determine whether the association between rs16969968 and smoking is modified by age at onset of regular smoking. DATA SOURCES: Primary data. STUDY SELECTION: Available genetic studies containing measures of CPD and the genotype of rs16969968 or its proxy. DATA EXTRACTION: Uniform statistical analysis scripts were run locally. Starting with 94,050 ever-smokers from 43 studies, we extracted the heavy smokers (CPD >20) and light smokers (CPD ≤10) with age-at-onset information, reducing the sample size to 33,348. Each study was stratified into early-onset smokers (age at onset ≤16 years) and late-onset smokers (age at onset >16 years), and a logistic regression of heavy vs light smoking with the rs16969968 genotype was computed for each stratum. Meta-analysis was performed within each age-at-onset stratum. DATA SYNTHESIS: Individuals with 1 risk allele at rs16969968 who were early-onset smokers were significantly more likely to be heavy smokers in adulthood (odds ratio [OR] = 1.45; 95% CI, 1.36-1.55; n = 13,843) than were carriers of the risk allele who were late-onset smokers (OR = 1.27; 95% CI, 1.21-1.33, n = 19,505) (P = .01). CONCLUSION: These results highlight an increased genetic vulnerability to smoking in early-onset smokers. |
| spellingShingle | Hartz, S Short, SE Saccone, N Culverhouse, R Chen, L Schwantes-An, T Coon, H Han, Y Stephens, S Sun, J Chen, X Ducci, F Dueker, N Franceschini, N Frank, J Geller, F Gubjartsson, D Hansel, N Jiang, C Keskitalo-Vuokko, K Liu, Z Lyytikäinen, L Michel, M Rawal, R Rosenberger, A Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers. |
| title | Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers. |
| title_full | Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers. |
| title_fullStr | Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers. |
| title_full_unstemmed | Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers. |
| title_short | Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers. |
| title_sort | increased genetic vulnerability to smoking at chrna5 in early onset smokers |
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