One-pot catalytic enantioselective synthesis of 2-pyrazolines

A scalable, one-pot, enantioselective catalytic synthesis of 2-pyrazolines from beta-substituted enones and hydrazines is described. Pivoting on a two-stage catalytic Michael addition/condensation strategy, the use of an aldehyde to generate a suitable hydrazone derivative of the hydrazine was found...

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Autori principali: Thomson, C, Barber, D, Dixon, D
Natura: Journal article
Lingua:English
Pubblicazione: Wiley 2019