A novel type of macrothrombocytopenia associated with a defect in α2,3-sialylation.

A novel type of macrothrombocytopenia associated with a defect in α2,3-sialylation.

We describe a novel type of human thrombocytopenia characterized by the appearance of giant platelets and variable neutropenia. Searching for the molecular defect, we found that neutrophils had strongly reduced sialyl-Lewis X and increased Lewis X surface expression, pointing to a deficiency in sial...

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Bibliographic Details
Main Authors: Jones, C, Denecke, J, Sträter, R, Stölting, T, Schunicht, Y, Zeuschner, D, Klumperman, J, Lefeber, D, Spelten, O, Zarbock, A, Kelm, S, Strenge, K, Haslam, S, Lühn, K, Stahl, D, Gentile, L, Schreiter, T, Hilgard, P, Beck-Sickinger, A, Marquardt, T, Wild, M
Format: Journal article
Language:English
Published: 2011

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