Structure of the ultra-high-affinity colicin E2 DNase-Im2 complex

How proteins achieve high-affinity binding to a specific protein partner while simultaneously excluding all others is a major biological problem that has important implications for protein design. We report the crystal structure of the ultra-high-affinity protein-protein complex between the endonucl...

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Bibliographic Details
Main Authors: Wojdyla, J, Fleishman, S, Baker, D, Kleanthous, C
Format: Journal article
Language:English
Published: 2012