In situ analysis of LKB1/STK11 mRNA expression in human normal tissues and tumours.

In situ analysis of LKB1/STK11 mRNA expression in human normal tissues and tumours.

The LKB1/STK11 serine/threonine kinase is mutated in Peutz-Jeghers' syndrome and acts as a tumour suppressor. Using northern blotting and RT-PCR, LKB1 has been reported to be expressed widely in human adult tissues, although in Xenopus the expression of its homologue, XEEK1, is apparently restr...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Rowan, A, Churchman, M, Jefferey, R, Hanby, A, Poulsom, R, Tomlinson, I
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	2000

Παρόμοια τεκμήρια

Identification of a novel mRNA species of the LKB1/STK11 Peutz-Jeghers serine/threonine kinase.
ανά: Churchman, M, κ.ά.
Έκδοση: (1999)

Germline mutations of the LKB1 (STK11) gene in Peutz-Jeghers patients.
ανά: Wang, Z, κ.ά.
Έκδοση: (1999)

Further observations on LKB1/STK11 status and cancer risk in Peutz-Jeghers syndrome.
ανά: Lim, W, κ.ά.
Έκδοση: (2003)

The role of LKB1 (STK11) in non-small cell lung cancer
ανά: Cahill, F
Έκδοση: (2017)

Tumor loss-of-function mutations in STK11/LKB1 induce cachexia
ανά: Puneeth Iyengar, κ.ά.
Έκδοση: (2023-04-01)

Sequence changes in predicted promoter elements of STK11/LKB1 are unlikely to contribute to Peutz-Jeghers syndrome.
ανά: Hearle, N, κ.ά.
Έκδοση: (2005)

The role of STK11/LKB1 in cancer biology: implications for ovarian tumorigenesis and progression
ανά: Jian Kang, κ.ά.
Έκδοση: (2024-10-01)

Allelic imbalance at the LKB1 (STK11) locus in tumours from patients with Peutz-Jeghers' syndrome provides evidence for a hamartoma-(adenoma)-carcinoma sequence.
ανά: Wang, Z, κ.ά.
Έκδοση: (1999)

mRNA expression profiling of phyllodes tumours of the breast: identification of genes important in the development of borderline and malignant phyllodes tumours.
ανά: Jones, A, κ.ά.
Έκδοση: (2008)

Roflumilast inhibits tumor growth and migration in STK11/LKB1 deficient pancreatic cancer
ανά: Shuman Zhang, κ.ά.
Έκδοση: (2024-03-01)

Loss of the tumour suppressor LKB1/STK11 uncovers a leptin-mediated sensitivity mechanism to mitochondrial uncouplers for targeted cancer therapy
ανά: Andriani Angelopoulou, κ.ά.
Έκδοση: (2024-07-01)

STK11 (LKB1) mutation suppresses ferroptosis in lung adenocarcinoma by facilitating monounsaturated fatty acid synthesis
ανά: Zou Qiang, κ.ά.
Έκδοση: (2024-01-01)

The Importance of <i>STK11</i>/<i>LKB1</i> Assessment in Non-Small Cell Lung Carcinomas
ανά: Baharia Mograbi, κ.ά.
Έκδοση: (2021-01-01)

<i>STK11/LKB1</i> Modulation of the Immune Response in Lung Cancer: From Biology to Therapeutic Impact
ανά: Elvire Pons-Tostivint, κ.ά.
Έκδοση: (2021-11-01)

Oral rapamycin reduces tumour burden and vascularization in Lkb1(+/-) mice.
ανά: Robinson, J, κ.ά.
Έκδοση: (2009)

The Wnt pathway, epithelial-stromal interactions, and malignant progression in phyllodes tumours.
ανά: Sawyer, E, κ.ά.
Έκδοση: (2002)

Allele loss and mutation screen at the Peutz-Jeghers (LKB1) locus (19p13.3) in sporadic ovarian tumours.
ανά: Wang, Z, κ.ά.
Έκδοση: (1999)

Mutations in normal breast tissue and breast tumours.
ανά: Tomlinson, I
Έκδοση: (2001)

Beta-catenin abnormalities and associated insulin-like growth factor overexpression are important in phyllodes tumours and fibroadenomas of the breast.
ανά: Sawyer, E, κ.ά.
Έκδοση: (2003)

Malignant phyllodes tumours show stromal overexpression of c-myc and c-kit.
ανά: Sawyer, E, κ.ά.
Έκδοση: (2003)

Genetic pathways of colorectal carcinogenesis rarely involve the PTEN and LKB1 genes outside the inherited hamartoma syndromes.
ανά: Wang, Z, κ.ά.
Έκδοση: (1998)

Somatic mutations in the Peutz-Jeghers (LKB1/STKII) gene in sporadic malignant melanomas.
ανά: Rowan, A, κ.ά.
Έκδοση: (1999)

Normal and Tumour Tissue mRNA Expressions of Telomerase Complex Genes in Several Types of Cancer
ανά: Emel Çalışkan Can, κ.ά.
Έκδοση: (2017-06-01)

STK11 genetic alterations in metastatic EGFR mutant lung cancer
ανά: Dandan Yin, κ.ά.
Έκδοση: (2025-02-01)

LKB1 biology: assessing the therapeutic relevancy of LKB1 inhibitors
ανά: Charles B. Trelford, κ.ά.
Έκδοση: (2024-06-01)

Elucidating the role of Lkb1 and mTOR in adipose tissue
ανά: Ziye Xu, κ.ά.
Έκδοση: (2019-01-01)

Unraveling the Deleterious Effects of Cancer-Driven STK11 Mutants through Conformational Sampling Approach
ανά: Merlin Lopus, κ.ά.
Έκδοση: (2016-01-01)

LKB1/AMPK and PKA control ABCB11 trafficking and polarization in hepatocytes.
ανά: László Homolya, κ.ά.
Έκδοση: (2014-01-01)

The LKB1 tumor suppressor as a biomarker in mouse and human tissues.
ανά: Yuji Nakada, κ.ά.
Έκδοση: (2013-01-01)

ATP and MO25alpha regulate the conformational state of the STRADalpha pseudokinase and activation of the LKB1 tumour suppressor.
ανά: Elton Zeqiraj, κ.ά.
Έκδοση: (2009-06-01)

STK Annual Meeting 2023
ανά: Pierre Brodard
Έκδοση: (2024-06-01)

LKB1 suppression promotes cardiomyocyte regeneration via LKB1-AMPK-YAP axis
ανά: Shuang Qu, κ.ά.
Έκδοση: (2022-09-01)

Clinical perspectives on the value of testing for STK11 and KEAP1 mutations in advanced NSCLC
ανά: Michelle Shiller, κ.ά.
Έκδοση: (2024-12-01)

Somatic mutations of <it>STK11</it> gene in human papillomavirus positive and negative penile cancer
ανά: Annunziata Clorinda, κ.ά.
Έκδοση: (2013-01-01)

Characterization of the E-cadherin/catenin complex in colorectal carcinoma cell lines.
ανά: El-Bahrawy, M, κ.ά.
Έκδοση: (2004)

Promoter hypermethylation leads to decreased APC mRNA expression in familial polyposis and sporadic colorectal tumours, but does not substitute for truncating mutations.
ανά: Segditsas, S, κ.ά.
Έκδοση: (2008)

Parameters for the Lyman Kutcher Burman (LKB) model of Normal Tissue Complication Probability (NTCP) for specific rectal complications observed in clinical practise.
ανά: Gulliford, S, κ.ά.
Έκδοση: (2012)

Association between LKB1 expression and prognosis of patients with solid tumours: an updated systematic review and meta-analysis
ανά: Yun Hong Ren, κ.ά.
Έκδοση: (2019-08-01)

Gene expression of the tumour suppressor LKB1 is mediated by Sp1, NF-Y and FOXO transcription factors.
ανά: Nicolas Lützner, κ.ά.
Έκδοση: (2012-01-01)

LKB1 regulates polarity remodeling and adherens junction formation in the Drosophila eye.
ανά: Amin, N, κ.ά.
Έκδοση: (2009)