In situ analysis of LKB1/STK11 mRNA expression in human normal tissues and tumours.

In situ analysis of LKB1/STK11 mRNA expression in human normal tissues and tumours.

The LKB1/STK11 serine/threonine kinase is mutated in Peutz-Jeghers' syndrome and acts as a tumour suppressor. Using northern blotting and RT-PCR, LKB1 has been reported to be expressed widely in human adult tissues, although in Xenopus the expression of its homologue, XEEK1, is apparently restr...

Bibliografske podrobnosti
Main Authors:	Rowan, A, Churchman, M, Jefferey, R, Hanby, A, Poulsom, R, Tomlinson, I
Format:	Journal article
Jezik:	English
Izdano:	2000

Podobne knjige/članki

Identification of a novel mRNA species of the LKB1/STK11 Peutz-Jeghers serine/threonine kinase.
od: Churchman, M, et al.
Izdano: (1999)

Germline mutations of the LKB1 (STK11) gene in Peutz-Jeghers patients.
od: Wang, Z, et al.
Izdano: (1999)

Further observations on LKB1/STK11 status and cancer risk in Peutz-Jeghers syndrome.
od: Lim, W, et al.
Izdano: (2003)

The role of LKB1 (STK11) in non-small cell lung cancer
od: Cahill, F
Izdano: (2017)

Tumor loss-of-function mutations in STK11/LKB1 induce cachexia
od: Puneeth Iyengar, et al.
Izdano: (2023-04-01)

Sequence changes in predicted promoter elements of STK11/LKB1 are unlikely to contribute to Peutz-Jeghers syndrome.
od: Hearle, N, et al.
Izdano: (2005)

The role of STK11/LKB1 in cancer biology: implications for ovarian tumorigenesis and progression
od: Jian Kang, et al.
Izdano: (2024-10-01)

Allelic imbalance at the LKB1 (STK11) locus in tumours from patients with Peutz-Jeghers' syndrome provides evidence for a hamartoma-(adenoma)-carcinoma sequence.
od: Wang, Z, et al.
Izdano: (1999)

mRNA expression profiling of phyllodes tumours of the breast: identification of genes important in the development of borderline and malignant phyllodes tumours.
od: Jones, A, et al.
Izdano: (2008)

Roflumilast inhibits tumor growth and migration in STK11/LKB1 deficient pancreatic cancer
od: Shuman Zhang, et al.
Izdano: (2024-03-01)

Loss of the tumour suppressor LKB1/STK11 uncovers a leptin-mediated sensitivity mechanism to mitochondrial uncouplers for targeted cancer therapy
od: Andriani Angelopoulou, et al.
Izdano: (2024-07-01)

STK11 (LKB1) mutation suppresses ferroptosis in lung adenocarcinoma by facilitating monounsaturated fatty acid synthesis
od: Zou Qiang, et al.
Izdano: (2024-01-01)

The Importance of <i>STK11</i>/<i>LKB1</i> Assessment in Non-Small Cell Lung Carcinomas
od: Baharia Mograbi, et al.
Izdano: (2021-01-01)

<i>STK11/LKB1</i> Modulation of the Immune Response in Lung Cancer: From Biology to Therapeutic Impact
od: Elvire Pons-Tostivint, et al.
Izdano: (2021-11-01)

Oral rapamycin reduces tumour burden and vascularization in Lkb1(+/-) mice.
od: Robinson, J, et al.
Izdano: (2009)

The Wnt pathway, epithelial-stromal interactions, and malignant progression in phyllodes tumours.
od: Sawyer, E, et al.
Izdano: (2002)

Allele loss and mutation screen at the Peutz-Jeghers (LKB1) locus (19p13.3) in sporadic ovarian tumours.
od: Wang, Z, et al.
Izdano: (1999)

Mutations in normal breast tissue and breast tumours.
od: Tomlinson, I
Izdano: (2001)

Beta-catenin abnormalities and associated insulin-like growth factor overexpression are important in phyllodes tumours and fibroadenomas of the breast.
od: Sawyer, E, et al.
Izdano: (2003)

Malignant phyllodes tumours show stromal overexpression of c-myc and c-kit.
od: Sawyer, E, et al.
Izdano: (2003)

Genetic pathways of colorectal carcinogenesis rarely involve the PTEN and LKB1 genes outside the inherited hamartoma syndromes.
od: Wang, Z, et al.
Izdano: (1998)

Somatic mutations in the Peutz-Jeghers (LKB1/STKII) gene in sporadic malignant melanomas.
od: Rowan, A, et al.
Izdano: (1999)

Normal and Tumour Tissue mRNA Expressions of Telomerase Complex Genes in Several Types of Cancer
od: Emel Çalışkan Can, et al.
Izdano: (2017-06-01)

STK11 genetic alterations in metastatic EGFR mutant lung cancer
od: Dandan Yin, et al.
Izdano: (2025-02-01)

LKB1 biology: assessing the therapeutic relevancy of LKB1 inhibitors
od: Charles B. Trelford, et al.
Izdano: (2024-06-01)

Elucidating the role of Lkb1 and mTOR in adipose tissue
od: Ziye Xu, et al.
Izdano: (2019-01-01)

Unraveling the Deleterious Effects of Cancer-Driven STK11 Mutants through Conformational Sampling Approach
od: Merlin Lopus, et al.
Izdano: (2016-01-01)

LKB1/AMPK and PKA control ABCB11 trafficking and polarization in hepatocytes.
od: László Homolya, et al.
Izdano: (2014-01-01)

The LKB1 tumor suppressor as a biomarker in mouse and human tissues.
od: Yuji Nakada, et al.
Izdano: (2013-01-01)

ATP and MO25alpha regulate the conformational state of the STRADalpha pseudokinase and activation of the LKB1 tumour suppressor.
od: Elton Zeqiraj, et al.
Izdano: (2009-06-01)

STK Annual Meeting 2023
od: Pierre Brodard
Izdano: (2024-06-01)

LKB1 suppression promotes cardiomyocyte regeneration via LKB1-AMPK-YAP axis
od: Shuang Qu, et al.
Izdano: (2022-09-01)

Clinical perspectives on the value of testing for STK11 and KEAP1 mutations in advanced NSCLC
od: Michelle Shiller, et al.
Izdano: (2024-12-01)

Somatic mutations of <it>STK11</it> gene in human papillomavirus positive and negative penile cancer
od: Annunziata Clorinda, et al.
Izdano: (2013-01-01)

Characterization of the E-cadherin/catenin complex in colorectal carcinoma cell lines.
od: El-Bahrawy, M, et al.
Izdano: (2004)

Promoter hypermethylation leads to decreased APC mRNA expression in familial polyposis and sporadic colorectal tumours, but does not substitute for truncating mutations.
od: Segditsas, S, et al.
Izdano: (2008)

Parameters for the Lyman Kutcher Burman (LKB) model of Normal Tissue Complication Probability (NTCP) for specific rectal complications observed in clinical practise.
od: Gulliford, S, et al.
Izdano: (2012)

Association between LKB1 expression and prognosis of patients with solid tumours: an updated systematic review and meta-analysis
od: Yun Hong Ren, et al.
Izdano: (2019-08-01)

Gene expression of the tumour suppressor LKB1 is mediated by Sp1, NF-Y and FOXO transcription factors.
od: Nicolas Lützner, et al.
Izdano: (2012-01-01)

LKB1 regulates polarity remodeling and adherens junction formation in the Drosophila eye.
od: Amin, N, et al.
Izdano: (2009)