No evidence for age-related differences in mtRNA quality in the female germline

Mitochondrial quality is implicated as a contributor to declining fertility with aging. We investigated mitochondrial transcripts in oocytes and their associated cumulus cells from mice of different ages using RNA-seq. Mice aged 3 weeks, 9 weeks, and 1 year were superovulated and 48 hr later, oocyte...

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Bibliographic Details
Main Authors: Hartley, FM, Alageel, A, Appeltant, R, Gray, N, Repapi, E, Wells, D, Williams, SA, Poulton, J
Format: Journal article
Language:English
Published: Bioscientifica 2022