Succinate: a new epigenetic hacker.
Epigenetic reprogramming is a feature of many human cancers. In this issue of Cancer Cell, Letouzé and colleagues describe DNA hypermethylation in paragangliomas harboring mutations in succinate dehydrogenase genes. These tumors accumulate succinate, which inhibits 2-oxoglutarate-dependent histone a...
| Main Authors: | , |
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| 格式: | Journal article |
| 语言: | English |
| 出版: |
2013
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