Phosphodiesterase 4 inhibition affects both the direct and indirect pathway: an electrophysiological study examining the tri-phasic response in the substantia nigra pars reticulata

Fronto-striatal circuits constitute the neurobiological basis of many neuropsychiatric disorders. Part of the intracellular signaling within these circuits, including its dopaminergic modulation, is regulated by the cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA) signaling cascade. Base...

Full description

Bibliographic Details
Main Authors: Heckman, P, Schweimer, J, Sharp, T, Prickaerts, J, Blokland, A
Format: Journal article
Language:English
Published: Springer Berlin Heidelberg 2017