A cluster of mutations in HLA-A2 alpha 2 helix abolishes peptide recognition by T cells.
In order to investigate the regions of HLA-A2 that control peptide-specific cytotoxic T lymphocyte (CTL) recognition, 37 HLA-A2 genes coding for 50 point mutations that span the alpha 2 helix were synthesized by the technique of saturation mutagenesis. Twenty-nine of these genes, which code for 41 p...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1991
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