A cluster of mutations in HLA-A2 alpha 2 helix abolishes peptide recognition by T cells.

A cluster of mutations in HLA-A2 alpha 2 helix abolishes peptide recognition by T cells.

In order to investigate the regions of HLA-A2 that control peptide-specific cytotoxic T lymphocyte (CTL) recognition, 37 HLA-A2 genes coding for 50 point mutations that span the alpha 2 helix were synthesized by the technique of saturation mutagenesis. Twenty-nine of these genes, which code for 41 p...

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Bibliografiska uppgifter
Huvudupphovsmän:	Moots, R, Matsui, M, Pazmany, L, Mcmichael, A, Frelinger, J
Materialtyp:	Journal article
Språk:	English
Publicerad:	1991

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