Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family

Benzodiazepines are psychoactive drugs with anxiolytic, sedative, skeletal muscle relaxant and amnestic properties. Recently triazolo-benzodiazepines have been also described as potent and highly selective protein interaction inhibitors of bromodomain and extra-terminal (BET) proteins, a family of t...

Полное описание

Библиографические подробности
Главные авторы: Filippakopoulos, P, Picaud, S, Fedorov, O, Keller, M, Wrobel, M, Morgenstern, O, Bracher, F, Knapp, S
Формат: Journal article
Язык:English
Опубликовано: 2012