Cardiac phenotype of mitochondrial creatine kinase knockout mice is modified on a pure C57BL/6 genetic background.

Cardiac phenotype of mitochondrial creatine kinase knockout mice is modified on a pure C57BL/6 genetic background.

UNLABELLED: Discrepant results for the phenotype of mitochondrial creatine kinase knockout mice (Mt-CK(-/-)) could be due to mixed genetic background and use of non-littermate controls. We therefore backcrossed with C57BL/6J for >8 generations, followed by extensive in vivo cardiac phenotypin...

Fuld beskrivelse

Bibliografiske detaljer
Main Authors:	Lygate, C, Hunyor, I, Medway, D, de Bono, J, Dawson, D, Wallis, J, Sebag-Montefiore, L, Neubauer, S
Format:	Journal article
Sprog:	English
Udgivet:	2009

Lignende værker

Chronic creatine kinase deficiency eventually leads to congestive heart failure, but severity is dependent on genetic background, gender and age
af: Lygate, C, et al.
Udgivet: (2012)

Chronic creatine kinase deficiency eventually leads to congestive heart failure, but severity is dependent on genetic background, gender and age.
af: Lygate, C, et al.
Udgivet: (2012)

The creatine kinase energy transport system in the failing mouse heart
af: Lygate, C, et al.
Udgivet: (2006)

Regulation of Myocardial Creatine Uptake by Intra- and Extracellular Creatine Levels
af: Makinen, K, et al.
Udgivet: (2008)

Adaptations to Maintain Energy Homeostasis Compensate for Creatine-Deficiency in GAMT Knockout Mice Following Myocardial Infarction, but May Contribute to Early Mitochondrial Pathology During Aging
af: Lygate, C, et al.
Udgivet: (2011)

The creatine kinase energy transport system in the failing mouse heart.
af: Lygate, C, et al.
Udgivet: (2007)

Creatine uptake in mouse hearts with genetically altered creatine levels.
af: ten Hove, M, et al.
Udgivet: (2008)

Impaired exercise capacity in cytosolic (M-CK) but not in mitochondrial creatine kinase knockout mice
af: Maass, A, et al.
Udgivet: (2002)

Complete absence of creatine but unaltered ATP levels in hearts from AGAT knockout mice
af: ten Hove, M, et al.
Udgivet: (2007)

Living without creatine: Unchanged exercise capacity and response to chronic myocardial infarction in creatine-deficient mice
af: Lygate, C, et al.
Udgivet: (2013)

Living without creatine: unchanged exercise capacity and response to chronic myocardial infarction in creatine-deficient mice.
af: Lygate, C, et al.
Udgivet: (2013)

GUANIDINOACETATE N-METHYLTRANSFERASE KNOCKOUT MICE EXHIBIT NORMAL LEFT VENTRICULAR REMODELLING, HAEMODYNAMICS AND SURVIVAL AFTER MYOCARDIAL INFARCTION DESPITE LACK OF PHOSPHOCREATINE
af: Lygate, C, et al.
Udgivet: (2010)

COMPENSATION FOR IMPAIRED MYOCARDIAL PHOSPHOTRANSFER IN GUANIDINOACETATE-N-METHYLTRANSFERASE KNOCKOUT MICE
af: Aksentijevic, D, et al.
Udgivet: (2010)

New insights into the creatine kinase-phosphocreatine energy buffer and transport system using mouse models of altered creatine content
af: Lygate, C, et al.
Udgivet: (2006)

Regulation of myocardial creatine uptake capacity in genetically altered mouse models
af: Ten Hove, M, et al.
Udgivet: (2007)

A role for thioredoxin-interacting protein (Txnip) in cellular creatine homeostasis.
af: Zervou, S, et al.
Udgivet: (2013)

Moderate elevation of intracellular creatine by targeting the creatine transporter protects mice from acute myocardial infarction.
af: Lygate, C, et al.
Udgivet: (2012)

REGULATION OF CELLULAR CREATINE HOMEOSTASIS: A ROLE FOR THIOREDOXIN INTERACTING PROTEIN (TXNIP)
af: Zervou, S, et al.
Udgivet: (2013)

Ribose supplementation alone or with elevated creatine does not preserve high energy nucleotides or cardiac function in the failing mouse heart
af: Faller, K, et al.
Udgivet: (2013)

Impaired cardiac contractile function in AGAT knockout mice devoid of creatine is rescued by homoarginine but not creatine
af: Faller, K, et al.
Udgivet: (2017)

Overexpression of mitochondrial creatine kinase preserves cardiac energetics without ameliorating murine chronic heart failure
af: Cao, F, et al.
Udgivet: (2020)

Creatine kinase knockout mice show left ventricular hypertrophy and dilatation, but unaltered remodeling post-myocardial infarction.
af: Nahrendorf, M, et al.
Udgivet: (2005)

Supernormal myocardial creatine and phosphocreatine concentrations lead to cardiac hypertrophy and heart failure - Insights from creatine transporter over-expression transgenic mice
af: Wallis, J, et al.
Udgivet: (2005)

Supra-normal (phospho-)creatine levels lead to heart failure in mice overexpressing the cardiac creatine transporter - a longitudinal study
af: ten Hove, M, et al.
Udgivet: (2006)

Supranormal myocardial creatine and phosphocreatine concentrations lead to cardiac hypertrophy and heart failure: insights from creatine transporter-overexpressing transgenic mice.
af: Wallis, J, et al.
Udgivet: (2005)

Analysis of skeletal muscle function in the C57BL6/SV129 syncoilin knockout mouse.
af: McCullagh, K, et al.
Udgivet: (2008)

Metabolic Inflexibility of Malonyl CoA Decarboxylase (MCD) Knockout Mice Leads to Cardiac Remodelling and High Mortality During Peri-Weaning Period
af: Aksentijevic, D, et al.
Udgivet: (2014)

Mitochondrial creatine kinase is critically necessary for normal myocardial high-energy phosphate metabolism.
af: Spindler, M, et al.
Udgivet: (2002)

Creatine reduces mitochondrial permeability transition pore opening in response to oxidative stress in vitro
af: Zervou, S, et al.
Udgivet: (2010)

A comparison of the behavior of C57BL/6 and C57BL/10 mice.
af: Deacon, R, et al.
Udgivet: (2007)

High energy phosphotransfer in the failing mouse heart-role of adenylate kinase and glycolytic enzymes
af: Aksentijevic, D, et al.
Udgivet: (2010)

Elevated Myocardial Creatine Protects Against Ischemia/Reperfusion Injury by Improving Cardiac Energetics
af: Lygate, C, et al.
Udgivet: (2011)

Changes in creatine transporter function during cardiac maturation in the rat.
af: Fischer, A, et al.
Udgivet: (2010)

Simultaneous decreases in the creatine transporter, creatine content and creatine kinase in an experimental dog model of heart failure
af: Boehm, E, et al.
Udgivet: (2001)

Chronic Creatine-deficiency is not the Underlying Cause of Cardiac Dysfunction in Mice Lacking the Creatine Biosynthetic Enzyme Arginine: glycine Amidinotransferase
af: Lygate, C, et al.
Udgivet: (2013)

Mitochondrial creatine kinase is critically necessary to maintain a normal profile of myocardial high-energy phosphates
af: Spindler, M, et al.
Udgivet: (2000)

Unchanged Mitochondrial Organization and Compartmentation in Creatine Deficient GAMT-/- Mouse Heart
af: Branovets, J, et al.
Udgivet: (2013)

Over-expression of mitochondrial creatine kinase in the murine heart improves functional recovery and protects against injury following ischaemia-reperfusion
af: Whittington, H, et al.
Udgivet: (2018)

Modulation of myocardial creatine transporter levels and the effects of gene regulation and post-translational modification on its function
af: Sebag-Montefiore, L
Udgivet: (2012)

High-energy phosphotransfer in the failing mouse heart: role of adenylate kinase and glycolytic enzymes.
af: Aksentijević, D, et al.
Udgivet: (2010)