DOT1L inhibition reveals a distinct subset of enhancers dependent on H3K79 methylation

DOT1L inhibition reveals a distinct subset of enhancers dependent on H3K79 methylation

Enhancer elements are a key regulatory feature of many important genes. Several general features including the presence of specific histone modifications are used to demarcate potentially active enhancers. Here we reveal that putative enhancers marked with H3 lysine 79 (H3K79) di or trimethylation (...

Full description

Bibliographic Details
Main Authors:	Godfrey, L, Crump, N, Thorne, R, Lau, I, Repapi, E, Dimou, D, Smith, A, Harman, J, Telenius, J, Oudelaar, A, Downes, D, Vyas, P, Hughes, J, Milne, T
Format:	Journal article
Published:	Springer Nature 2019

Similar Items

DOT1L inhibition reveals a distinct subset of enhancers dependent on H3K79 methylation
by: Laura Godfrey, et al.
Published: (2019-06-01)

H3K79me2/3 controls enhancer–promoter interactions and activation of the pan-cancer stem cell marker PROM1/CD133 in MLL-AF4 leukemia cells
by: Godfrey, L, et al.
Published: (2020)

DOT1L and H3K79 methylation in transcription and genomic stability
by: Wood, K, et al.
Published: (2018)

DOT1L and H3K79 Methylation in Transcription and Genomic Stability
by: Katherine Wood, et al.
Published: (2018-02-01)

A revised model for promoter competition based on multi-way chromatin interactions at the α-globin locus
by: Oudelaar, A, et al.
Published: (2019)

DeepC: Predicting 3D genome folding using megabase-scale transfer learning
by: Schwessinger, R, et al.
Published: (2020)

Robust detection of chromosomal interactions from small numbers of cells using low-input Capture-C
by: Oudelaar, A, et al.
Published: (2017)

Integrative analysis of DNA methylation in discordant twins unveils distinct architectures of systemic sclerosis subsets
by: Paula S. Ramos, et al.
Published: (2019-04-01)

Distinct Volume Subsets
by: Conlon, David, et al.
Published: (2015)

MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia.
by: Kerry, J, et al.
Published: (2017)

Histone H3K79 methylation by DOT1L promotes Aurora B localization at centromeres in mitosis
by: Dan Yang, et al.
Published: (2023-08-01)

A gain-of-function single nucleotide variant creates a new promoter which acts as an orientation-dependent enhancer-blocker
by: Bozhilov, YK, et al.
Published: (2021)

Sustained MYB activity is necessary for oncogenic transcription in KMT2A-rearranged acute lymphoblastic leukemia through enhancer-promoter interactions and epigenetic modifications at enhancers
by: Lau, I-J, et al.
Published: (2023)

Direct screening for chromatin status on DNA barcodes in yeast delineates the regulome of H3K79 methylation by Dot1
by: Hanneke Vlaming, et al.
Published: (2016-12-01)

Dynamic Runx1 chromatin boundaries affect gene expression in hematopoietic development
by: Owens, DDG, et al.
Published: (2022)

MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia
by: Jon Kerry, et al.
Published: (2017-01-01)

Identification of distinct polarized macrophage subsets in inflammatory arthritis
by: Baeten D, et al.
Published: (2010-11-01)

MLL-AF4 binds directly to a BCL-2 specific enhancer and modulates H3K27 acetylation.
by: Godfrey, L, et al.
Published: (2016)

A Distinct DNA Methylation Shift in a Subset of Glioma CpG Island Methylator Phenotypes during Tumor Recurrence
by: Camila Ferreira de Souza, et al.
Published: (2018-04-01)

BET inhibition disrupts transcription but retains enhancer-promoter contact
by: Nicholas Crump, et al.
Published: (2019)

Degree of Recruitment of DOT1L to MLL-AF9 Defines Level of H3K79 Di- and Tri-methylation on Target Genes and Transformation Potential
by: Aravinda Kuntimaddi, et al.
Published: (2015-05-01)

Evidence that ubiquitylated H2B corrals hDot1L on the nucleosomal surface to induce H3K79 methylation
by: Linjiao Zhou, et al.
Published: (2016-02-01)

DOT-1.1-dependent H3K79 methylation promotes normal meiotic progression and meiotic checkpoint function in C. elegans.
by: Laura I Lascarez-Lagunas, et al.
Published: (2020-10-01)

Linking the cell cycle to histone modifications: Dot1, G1/S, and cycling K79me2.
by: Mellor, J
Published: (2009)

Low-input capture-C: A chromosome conformation capture assay to analyze chromatin architecture in small numbers of cells
by: Oudelaar, AM, et al.
Published: (2017)

Distinct fibroblast subsets drive inflammation and damage in arthritis
by: Croft, AP, et al.
Published: (2019)

Single-allele chromatin interactions identify regulatory hubs in dynamic compartmentalized domains
by: Oudelaar, A, et al.
Published: (2018)

Architecture and dynamics of an A-kinase anchoring protein 79 (AKAP79) signaling complex.
by: Gold, MG, et al.
Published: (2011)

Enhancers predominantly regulate gene expression during differentiation via transcription initiation
by: Larke, MSC, et al.
Published: (2021)

Regulation of the Migration of Distinct Dendritic Cell Subsets
by: Meng Feng, et al.
Published: (2021-02-01)

Dot1-dependent histone H3K79 methylation promotes the formation of meiotic double-strand breaks in the absence of histone H3K4 methylation in budding yeast.
by: Mohammad Bani Ismail, et al.
Published: (2014-01-01)

Low-input Capture-C: A Chromosome Conformation Capture Assay to Analyze Chromatin Architecture in Small Numbers of Cells
by: A. Marieke Oudelaar, et al.
Published: (2017-12-01)

BET inhibition disrupts transcription but retains enhancer-promoter contact
by: Nicholas T. Crump, et al.
Published: (2021-01-01)

Epigenetic drug library screening reveals targeting DOT1L abrogates NAD+ synthesis by reprogramming H3K79 methylation in uveal melanoma
by: Xiang Gu, et al.
Published: (2023-01-01)

A gain-of-function single nucleotide variant creates a new promoter which acts as an orientation-dependent enhancer-blocker
by: Yavor K. Bozhilov, et al.
Published: (2021-06-01)

Distinctive CD26 Expression on CD4 T-Cell Subsets
by: Oscar J. Cordero, et al.
Published: (2021-10-01)

Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis
by: Fumitaka Mizoguchi, et al.
Published: (2018-02-01)

Subsets of Visceral Adipose Tissue Nuclei with Distinct Levels of 5-Hydroxymethylcytosine.
by: Ping Yu, et al.
Published: (2016-01-01)

Dot1-dependent histone H3K79 methylation promotes activation of the Mek1 meiotic checkpoint effector kinase by regulating the Hop1 adaptor.
by: David Ontoso, et al.
Published: (2013-01-01)

Rheumatoid synovial fibroblasts differentiate into distinct subsets in the presence of cytokines and cartilage
by: Croft, AP, et al.
Published: (2016)