Selective metal-site-guided arylation of proteins

We describe a palladium-mediated S-arylation method that exploits natural metal-binding motifs to ensure high site-selectivity for a proximal reactive residue. This allows the chemical identification not only of proteins that bind metals but the environment of the metal binding site itself through p...

詳細記述

書誌詳細
主要な著者: Willwacher, J, Raj, R, Mohammed, S, Davis, B
フォーマット: Journal article
言語:English
出版事項: American Chemical Society 2016