β-Catenin activation synergizes with Pten loss and Myc overexpression in Notch-independent T-ALL.
Wnt signaling is important for T-cell differentiation at the early CD4(-)CD8(-) stage and is subsequently downregulated with maturation. To assess the importance of this downregulation, we generated a mouse line (R26-βcat) in which high levels of active β-catenin are maintained throughout T-cell dev...
| Auteurs principaux: | , , , , , |
|---|---|
| Format: | Journal article |
| Langue: | English |
| Publié: |
2013
|