β-Catenin activation synergizes with Pten loss and Myc overexpression in Notch-independent T-ALL.

Wnt signaling is important for T-cell differentiation at the early CD4(-)CD8(-) stage and is subsequently downregulated with maturation. To assess the importance of this downregulation, we generated a mouse line (R26-βcat) in which high levels of active β-catenin are maintained throughout T-cell dev...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों: Kaveri, D, Kastner, P, Dembélé, D, Nerlov, C, Chan, S, Kirstetter, P
स्वरूप: Journal article
भाषा:English
प्रकाशित: 2013