β-Catenin activation synergizes with Pten loss and Myc overexpression in Notch-independent T-ALL.

Wnt signaling is important for T-cell differentiation at the early CD4(-)CD8(-) stage and is subsequently downregulated with maturation. To assess the importance of this downregulation, we generated a mouse line (R26-βcat) in which high levels of active β-catenin are maintained throughout T-cell dev...

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書目詳細資料
Main Authors: Kaveri, D, Kastner, P, Dembélé, D, Nerlov, C, Chan, S, Kirstetter, P
格式: Journal article
語言:English
出版: 2013