Gene amplification of the multidrug resistance 1 gene of Plasmodium vivax isolates from Thailand, Laos, and Myanmar.
Plasmodium vivax mdr1 gene amplification, quantified by real-time PCR, was significantly more common on the western Thailand border (6 of 66 samples), where mefloquine pressure has been intense, than elsewhere in southeast Asia (3 of 149; P = 0.02). Five coding mutations in pvmdr1, independent of ge...
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| Hlavní autoři: |
Imwong, M,
Pukrittayakamee, S,
Pongtavornpinyo, W,
Nakeesathit, S,
Nair, S,
Newton, P,
Nosten, F,
Anderson, T,
Dondorp, A,
Day, N,
White, N |
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| Médium: | Journal article
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| Jazyk: | English |
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| Vydáno: |
2008
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