Towards a small molecule inhibitor of Lactate Dehydrogenase-A
Lactate Dehydrogenase-A (LDH-A) is up-regulated in a broad array of cancers and is associated with poor prognosis. Involved in the hypoxic response, LDH-A is a HIF-1 target and is responsible for the enzymatic reduction of pyruvate to lactate. This is important for several reasons, chiefly (1) the r...
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| Format: | Thesis |
| Language: | English |
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2011
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