Cytoplasmic expression systems triggered by mRNA yield increased gene expression in post-mitotic neurons

Cytoplasmic expression systems triggered by mRNA yield increased gene expression in post-mitotic neurons

Non-viral vectors are promising vehicles for gene therapy but delivery of plasmid DNA to post-mitotic cells is challenging as nuclear entry is particularly inefficient. We have developed and evaluated a hybrid mRNA/DNA system designed to bypass the nuclear barrier to transfection and facilitate cyto...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Farrow, P, Barrett, L, Stevenson, M, Fisher, K, Finn, J, Spice, R, Allan, M, Berry, M, Logan, A, Seymour, L, Read, M
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	Oxford University Press 2006
Θέματα:	Life Sciences

Παρόμοια τεκμήρια

A versatile reducible polycation-based system for efficient delivery of a broad range of nucleic acids.
ανά: Read, M, κ.ά.
Έκδοση: (2005)

Fasting induced cytoplasmic Fto expression in some neurons of rat hypothalamus.
ανά: Predrag Vujovic, κ.ά.
Έκδοση: (2013-01-01)

Peptide-mediated RNA delivery: a novel approach for enhanced transfection of primary and post-mitotic cells
ανά: Bettinger, T, κ.ά.
Έκδοση: (2001)

Peptide-mediated RNA delivery: a novel approach for enhanced transfection of primary and post-mitotic cells.
ανά: Bettinger, T, κ.ά.
Έκδοση: (2001)

PD-1 in human NK cells: evidence of cytoplasmic mRNA and protein expression
ανά: Francesca R. Mariotti, κ.ά.
Έκδοση: (2019-03-01)

In vitro evaluation of a 'stealth' adenoviral vector for targeted gene delivery to adult mammalian neurones.
ανά: Sims, K, κ.ά.
Έκδοση: (2009)

Double Duty: Mitotic Kinesins and Their Post-Mitotic Functions in Neurons
ανά: Nadine F. Joseph, κ.ά.
Έκδοση: (2021-01-01)

Mitotic chromosomes scale to nuclear-cytoplasmic ratio and cell size in Xenopus
ανά: Coral Y Zhou, κ.ά.
Έκδοση: (2023-04-01)

Condensin I subunit Cap-G is essential for proper gene expression during the maturation of post-mitotic neurons
ανά: Amira Hassan, κ.ά.
Έκδοση: (2020-04-01)

Adenosine Receptor mRNA Expression in Frontal Cortical Neurons in Schizophrenia
ανά: Smita Sahay, κ.ά.
Έκδοση: (2023-12-01)

Cohesin Removal Reprograms Gene Expression upon Mitotic Entry
ανά: Perea-Resa, Carlos, κ.ά.
Έκδοση: (2022)

Cohesin Removal Reprograms Gene Expression upon Mitotic Entry
ανά: Perea-Resa, Carlos, κ.ά.
Έκδοση: (2021)

Increased cytoplasmic expression of PETase enzymes in E. coli
ανά: Luke M. Carter, κ.ά.
Έκδοση: (2024-11-01)

The Dynamics of Cytoplasmic mRNA Metabolism
ανά: Eisen, Timothy J, κ.ά.
Έκδοση: (2021)

Wolbachia superinfections and the expression of cytoplasmic incompatibility.
ανά: Sinkins, S, κ.ά.
Έκδοση: (1995)

Epilepsy protein Efhc1/myoclonin1 is expressed in cells with motile cilia but not in neurons or mitotic apparatuses in brain
ανά: Toshimitsu Suzuki, κ.ά.
Έκδοση: (2020-12-01)

MELK expression correlates with tumor mitotic activity but is not required for cancer growth
ανά: Christopher J Giuliano, κ.ά.
Έκδοση: (2018-02-01)

Poliovirus 2A protease triggers a selective nucleo-cytoplasmic redistribution of splicing factors to regulate alternative pre-mRNA splicing.
ανά: Enrique Álvarez, κ.ά.
Έκδοση: (2013-01-01)

Cytoplasmic retention and degradation of a mitotic inducer enable plant infection by a pathogenic fungus
ανά: Paola Bardetti, κ.ά.
Έκδοση: (2019-10-01)

Exclusion of NFAT5 from mitotic chromatin resets its nucleo-cytoplasmic distribution in interphase.
ανά: Anaïs Estrada-Gelonch, κ.ά.
Έκδοση: (2009-09-01)

Cytoplasmic expression of LGR5 in pancreatic adenocarcinoma.
ανά: Nobumasa eMizuno, κ.ά.
Έκδοση: (2013-09-01)

Cytoplasmic polyadenylation in S. pombe
ανά: Stevenson, A, κ.ά.
Έκδοση: (2005)

SBDS expression and localization at the mitotic spindle in human myeloid progenitors.
ανά: Claudia Orelio, κ.ά.
Έκδοση: (2009-01-01)

Cytoplasmic polyadenylation and cytoplasmic polyadenylation element-dependent mRNA regulation are involved in Xenopus retinal axon development.
ανά: Lin, A, κ.ά.
Έκδοση: (2009)

Outside-in signaling through the major histocompatibility complex class-I cytoplasmic tail modulates glutamate receptor expression in neurons
ανά: Brett A. Eyford, κ.ά.
Έκδοση: (2023-08-01)

Assessment of prognostic significance of cytoplasmic survivin expression in advanced oesophageal cancer.
ανά: G Wallner, κ.ά.
Έκδοση: (2004-10-01)

Cytoplasmic Control of Sense-Antisense mRNA Pairs
ανά: Flore Sinturel, κ.ά.
Έκδοση: (2015-09-01)

Sorting mRNA Molecules for Cytoplasmic Transport and Localization
ανά: Nathalie Neriec, κ.ά.
Έκδοση: (2018-11-01)

GABAergic Neurons in the Rat Medial Septal Complex Express Relaxin-3 Receptor (RXFP3) mRNA
ανά: Hector Albert-Gascó, κ.ά.
Έκδοση: (2018-01-01)

Self-assembling poly(l-lysine)/DNA complexes capable of integrin-mediated cellular uptake and gene expression
ανά: Carlisle, R, κ.ά.
Έκδοση: (1999)

Robust trigger wave speed in Xenopus cytoplasmic extracts
ανά: Jo-Hsi Huang, κ.ά.
Έκδοση: (2024-07-01)

Activation of JNK triggers release of Brd4 from mitotic chromosomes and mediates protection from drug-induced mitotic stress.
ανά: Akira Nishiyama, κ.ά.
Έκδοση: (2012-01-01)

Effect of cytoplasm on expression of genes for resistance to Puccinia triticina
ανά: Jerković Zoran I., κ.ά.
Έκδοση: (2007-01-01)

Identification of Drosophila mitotic genes by combining co-expression analysis and RNA interference.
ανά: Maria Patrizia Somma, κ.ά.
Έκδοση: (2008-07-01)

CRISPR/Cas9-mediated gene knock-down in post-mitotic neurons.
ανά: Christoph Straub, κ.ά.
Έκδοση: (2014-01-01)

Comparison of the contributions of the nuclear and cytoplasmic compartments to global gene expression in human cells
ανά: Lynch Ronald M, κ.ά.
Έκδοση: (2007-09-01)

TET3-mediated accumulation of DNA hydroxymethylation contributes to the activity-dependent gene expression of Rab3a in post-mitotic neurons
ανά: Kun Luo, κ.ά.
Έκδοση: (2021-09-01)

Metadherin mRNA expression in hepatocellular carcinoma
ανά: Nevein M. Al-sheikh, κ.ά.
Έκδοση: (2018-10-01)

Satellite glia not DRG neurons constitutively activate EGFR but EGFR inactivation is not correlated with axon regeneration
ανά: Zubair Ahmed, κ.ά.
Έκδοση: (2010-09-01)

Transient focal ischemia triggers neuronal expression of GAT-3 in the rat perilesional cortex
ανά: Marcello Melone, κ.ά.
Έκδοση: (2003-10-01)