Cytoplasmic expression systems triggered by mRNA yield increased gene expression in post-mitotic neurons

Cytoplasmic expression systems triggered by mRNA yield increased gene expression in post-mitotic neurons

Non-viral vectors are promising vehicles for gene therapy but delivery of plasmid DNA to post-mitotic cells is challenging as nuclear entry is particularly inefficient. We have developed and evaluated a hybrid mRNA/DNA system designed to bypass the nuclear barrier to transfection and facilitate cyto...

书目详细资料
Main Authors:	Farrow, P, Barrett, L, Stevenson, M, Fisher, K, Finn, J, Spice, R, Allan, M, Berry, M, Logan, A, Seymour, L, Read, M
格式:	Journal article
语言:	English
出版:	Oxford University Press 2006
主题:	Life Sciences

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